In this section we list research results and publications, which have used the EPHect tools in their studies, along with the publications of the tools.
— Research results
— EPHect EPQ translations
— EPHect-based protocols
— EPHect publications
— Global Study of Women's Health / Women's Health Symptom Survey (WHSS)
Hrishikesh Munshi, Nayna Barada, Sandhya Anand, Rahul K Gajbhiye. Pregnancy outcomes in women with different endometriosis lesion types: A review of current evidence. J Obstet Gynaecol Res 2025;51(5):e16321.
Lysia Demetriou, Danielle Perro, Lydia Coxon, Michal Krassowski, Claire E Lunde, Joana Ferreira-Gomes, Ana Charrua, Pedro Abreu-Mendes, Lars Arendt-Nielsen, Qasim Aziz, Judy Birch, Kurtis Garbutt, Andrew Horne, Anja Hoffman, Lone Hummelshoj, Jane Meijlink, Maik Obendorf, Esther Pogatzki-Zahn, Naoko Sasamoto, Kathryn Terry, Rolf-Detlef Treede, Allison Vitonis, Jan Vollert, Nilufer Rahmioglu, Christian M Becker, Francisco Cruz, Stacey A Missmer, Krina Zondervan, Christine B Sieberg, Jens Nagel, Katy Vincent. Exploring the value of a well-established conditioned pain modulation paradigm in women: a Translational Research in Pelvic Pain (TRiPP) study. Front Pain Res (Lausanne) 2025;6:1439563.
Lydia Coxon, Celia Lugt, Andrew W Horne, Emma Evans, Pedro Abreu-Mendes, Lars Arendt-Nielsen, Qasim Aziz, Christian M Becker, Judy Birch, Ana Charrua, Lysia Demetriou, Joana Ferreira-Gomes, Anja Hoffman, Lone Hummelshoj, Michal Krassowski, Claire E Lunde, Jane Meijlink, Stacey A Missmer, Danielle Perro, Krina T Zondervan, Christine B Sieberg, Francisco Cruz, Jens Nagel, Katy Vincent. Symptom flares in women with chronic pelvic pain: Questionnaire study within a cohort study (translational research in pelvic pain (TRiPP)). BJOG. 2024;131(13):1832-40.
Stefanie Burghaus, Predrag Drazic, Monika Wölfler, Sylvia Mechsner, Magdalena Zeppernick, Ivo Meinhold-Heerlein, Michael D Mueller, Ralf Rothmund, Paola Vigano, Christian M Becker, Krina T Zondervan, Matthias W Beckmann, Peter A Fasching, Sibylle Berner-Gatz, Felix S Grünewald, Martin Hund, Peter Kastner, Martin Klammer, Ruediger P Laubender, Heike Wegmeyer, Ursula-Henrike Wienhues-Thelen, Stefan P Renner. Multicenter evaluation of blood-based biomarkers for the detection of endometriosis and adenomyosis: A prospective non-interventional study. Int J Gynaecol Obstet 2024;164(1):305-14.
Naoko Sasamoto, Long Ngo, Allison F Vitonis, Simon T Dillon, Pooja Prasad, Marc R Laufer, Sawsan As-Sanie, Andrew Schrepf, Stacey A Missmer, Towia A Libermann, Kathryn L Terry. Plasma proteins and persistent postsurgical pelvic pain among adolescents and young adults with endometriosis. Am J Obstet Gynecol 2024;231(2):240.e1-240.e11.
Hrishikesh Munshi, Tabassum Khan, Shagufta Khan, Pramathes DasMahapatra, Sheila Balakrishnan, Chelana Nirmala, Vinita Das, Ketki Kulkarni, Bimal M John, Amiya Majumdar, CV Sowmini, Aarti Srivastava, Komal Khade, Rahul K Gajbhiye. Determinants of Conception and Adverse Pregnancy Outcomes in Women with Endometriosis: A Longitudinal Study. Reprod Sci 2024;31(6):1757-62.
Bethan Swift, Bahar Taneri, Christian M Becker, Hasan Basarir, Huseyin Naci, Stacey A Missmer, Krina T Zondervan, Nilufer Rahmioglu. Prevalence, diagnostic delay and economic burden of endometriosis and its impact on quality of life: results from an Eastern Mediterranean population. Eur J Public Health 2024;34(2):244-252.
Qian Feng, Nina Shigesi, Jun Guan, Nilufer Rahmioglu, Mona Bafadhel, Kevin Paddon, Carol Hubbard, Krina Zondervan, Christian Becker, Karin Hellner. Elevated basophil count is associated with increased risk of endometriosis. Reprod Fertil 2024;5(3):RAF-23-0090.
Jennifer M Mongiovi, Britani Wallace, McKenzie Goodwin, Allison F Vitonis, Sarah Karevicius, Amy L Shafrir, Naoko Sasamoto, Amy D DiVasta, Christine B Sieberg, Kathryn L Terry, Stacey A Missmer. Differences in characteristics and use of complementary and alternative methods for coping with endometriosis-associated acyclic pelvic pain across adolescence and adulthood. Front Reprod Health 2024;5:1306380.
Amy L Shafrir, Britani Wallace, Ashley Laliberte, Allison F Vitonis, Christine B Sieberg, Kathryn L Terry, Stacey A Missmer. Pelvic pain symptoms and endometriosis characteristics in relation to oxidative stress among adolescents and adults with and without surgically-confirmed endometriosis. F1000Res 2024;13:34.
Lydia Coxon, Jan Vollert, Danielle Perro, Claire E Lunde, Joana Ferreira-Gomes, Ana Charrua, Pedro Abreu-Mendes, Michal Krassowski, Judy Birch, Jane Meijlink, Lone Hummelshoj, Anja Hoffmann, Qasim Aziz, Lars Arendt-Nielsen, Esther Pogatzki-Zahn, Emma Evans, Lysia Demetriou, Stephen B McMahon, Stacey A Missmer, Christian M Becker, Krina T Zondervan, Andrew W Horne, Francisco Cruz, Christine B Sieberg, Rolf-Detlef Treede, Jens Nagel, Katy Vincent. Comprehensive quantitative sensory testing shows altered sensory function in women with chronic pelvic pain: results from the Translational Research in Pelvic Pain (TRiPP) Study. Pain 2023;164(11):2528-2539.
Abdelrahman Yousif, Mary DePari, Allison F Vitonis, Holly R Harris, Amy L Shafrir, Kathryn L Terry, Stacey A Missmer, Naoko Sasamoto. Visualized peritoneal fluid variation in adolescents and young adults with endometriosis: is there more to it? Front Reprod Health 2023;5:1297907.
Bethan Swift, Bahar Taneri, Ilgin Cagnan, Christian M Becker, Krina T Zondervan, Maria A Quigley, Nilufer Rahmioglu. Predictors and trends of Caesarean section and breastfeeding in the Eastern Mediterranean region: data from the cross-sectional Cyprus Women’s Health Research (COHERE) Initiative. PlosOne 2023;18(7):e0287469.
Lysia Demetriou, Michal Krassowski, Pedro Abreu Mendes, Kurtis Garbutt, Allison F Vitonis, Elizabeth Wilkins, Lydia Coxon, Lars Arendt-Nielsen, Qasim Aziz, Judy Birch, Andrew W Horne, Anja Hoffman, Lone Hummelshoj, Claire E Lunde, Jane Meijlink, Danielle Perro, Nilufer Rahmioglu, Kathryn L Terry, Esther Pogatzki-Zahn, Christine B Sieberg, Rolf-Detlef Treede, Christian M Becker, Francisco Cruz, Stacey A Missmer, Krina T Zondervan, Jens Nagel, Katy Vincent. Clinical profiling of specific diagnostic subgroups of women with chronic pelvic pain. Front Reprod Health 2023;5:1140857.
Yifan Wang, Rebecca A Dragovic, Erin Greaves, Christian M Becker, Jennifer H Southcombe. Macrophages and small extracellular vesicle mediated-intracellular communication in the peritoneal microenvironment: Impact on endometriosis development. Front Reprod Health 2023;5:1130849.
Sally Mortlock, Sahar Houshdaran, Idit Kosti, Nilufer Rahmioglu, Camran Nezhat, Allison F Vitonis, Shan V Andrews, Parker Grosjean, Manish Paranjpe, Andrew W Horne, Alison Jacoby, Jeannette Lager, Jessica Opoku-Anane, Kim Chi Vo, Evelina Manvelyan, Sushmita Sen, Zhanna Ghukasyan, Frances Collins, Xavier Santamaria, Philippa Saunders, Kord Kober, Allan F McRae, Kathryn L Terry, Júlia Vallvé-Juanico, Christian Becker, Peter A W Rogers, Juan C Irwin, Krina Zondervan, Grant W Montgomery, Stacey Missmer, Marina Sirota, Linda Giudice. Global endometrial DNA methylation analysis reveals insights into mQTL regulation and associated endometriosis disease risk and endometrial function. Commun Biol 2023;6(1):780.
Naoko Sasamoto, Long Ngo, Allison F Vitonis, Simon T Dillon, Christine B Sieberg, Stacey A Missmer, Towia A Libermann, Kathryn L Terry. Plasma proteomic profiles of pain subtypes in adolescents and young adults with endometriosis. Sasamoto N, Ngo L, Vitonis AF, Dillon ST, Sieberg CB, Missmer SA, Libermann TA, Terry KL. Hum Reprod 2023;38(8):1509-19.
Naoko Sasamoto, Amy L Shafrir, Britani M Wallace, Allison F Vitonis, Cameron J Fraer, Jenny Sadler Gallagher, Mary DePari, Marzieh Ghiasi, Marc R Laufer, Christine B Sieberg, Amy D DiVasta, Andrew Schrepf, Sawsan As-Sanie, Kathryn L Terry, Stacey A Missmer. Trends in pelvic pain symptoms over 2 years of follow-up among adolescents and young adults with and without endometriosis. Pain 2023;164(3):613-24.
Nilufer Rahmioglu, Sally Mortlock, Marzieh Ghiasi, Peter L Møller, Lilja Stefansdottir , Geneviève Galarneau, Constance Turman, Rebecca Danning, Matthew H Law, Yadav Sapkota, Paraskevi Christofidou, Sini Skarp, Ayush Giri, Karina Banasik , Michal Krassowski, Maarja Lepamets, Błażej Marciniak, Margit Nõukas, Danielle Perro, Eeva Sliz, Marta Sobalska-Kwapis, Gudmar Thorleifsson, Nura F Topbas-Selcuki, Allison Vitonis, David Westergaard, Ragnheidur Arnadottir, Kristoffer S Burgdorf, Archie Campbell, Cecilia S K Cheuk, Caterina Clementi , James Cook , Immaculata De Vivo , Amy DiVasta, O Dorien, Jacqueline F Donoghue, Todd Edwards, Pierre Fontanillas, Jenny N Fung , Reynir T Geirsson, Jane E Girling , Paivi Harkki, Holly R Harris, Martin Healey, Oskari Heikinheimo, Sarah Holdsworth-Carson, Isabel C Hostettler, Henry Houlden, Sahar Houshdaran, Juan C Irwin, Marjo-Riitta Jarvelin, Yoichiro Kamatani, Stephen H Kennedy, Ewa Kepka, Johannes Kettunen, Michiaki Kubo, Bartosz Kulig, Venla Kurra, Hannele Laivuori, Marc R Laufer, Cecilia M Lindgren, Stuart MacGregor, Massimo Mangino, Nicholas G Martin, Charoula Matalliotaki, Michail Matalliotakis, Alison D Murray, Anne Ndungu, Camran Nezhat, Catherine M Olsen, Jessica Opoku-Anane, Sandosh Padmanabhan, Manish Paranjpe, Maire Peters, Grzegorz Polak, David J Porteous, Joseph Rabban, Kathyrn M Rexrode, Hanna Romanowicz, Merli Saare, Liisu Saavalainen, Andrew J Schork, Sushmita Sen, Amy L Shafrir, Anna Siewierska-Górska, Marcin Słomka, Blair H Smith, Beata Smolarz , Tomasz Szaflik , Krzysztof Szyłło, Atsushi Takahashi, Kathryn L Terry, Carla Tomassetti, Susan A Treloar, Arne Vanhie, Katy Vincent, Kim C Vo, David J Werring, Eleftheria Zeggini, Maria I Zervou; DBDS Genomic Consortium; FinnGen Study; FinnGen Endometriosis Taskforce; Celmatix Research Team; 23andMe Research Team; Sosuke Adachi, Julie E Buring, Paul M Ridker, Thomas D'Hooghe, George N Goulielmos, Dharani K Hapangama, Caroline Hayward, Andrew W Horne, Siew-Kee Low, Hannu Martikainen, Daniel I Chasman, Peter A W Rogers, Philippa T Saunders, Marina Sirota, Tim Spector, Dominik Strapagiel, Joyce Y Tung, David C Whiteman, Linda C Giudice, Digna R Velez-Edwards, Outi Uimari, Peter Kraft, Andres Salumets, Dale R Nyholt, Reedik Mägi, Kari Stefansson, Christian M Becker, Piraye Yurttas-Beim, Valgerdur Steinthorsdottir, Mette Nyegaard, Stacey A Missmer, Grant W Montgomery , Andrew P Morris, Krina T Zondervan. The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions. Nat Genet 2023;55(3):423-36.
N Salmeri, J Ottolina, L Bartiromo, M Schimberni, C Dolci, S Ferrari, R Villanacci, S Arena, N Berlanda, L Buggio, A Di Cello, E Fuggetta, F Maneschi, C Massarotti, A Mattei, F Perelli, I Pino, M G Porpora, D Raimondo, V Remorgida, R Seracchioli, A Ticino, P Viganò, M Vignali, F Zullo, E Zupi, L Pagliardini, M Candiani. 'Guess who'? An Italian multicentric study on pigmentation traits prevalence in endometriosis localizations. Eur J Obstet Gynecol Reprod Biol. 2022;274:5-12.
Aishwarya V Bhurke, Pramathes DasMahapatra, Sheila Balakrishnan, Shagufta A Khan, Sally Mortlock, Vinita Das, Nirmala Chellamma, Sowmini Cheruvara Vadakkathil, Aarti Srivastava, Amiya Majumdar, Achhelal Pasi, Geetanjali Sachdeva, Grant W Montgomery, Rahul K Gajbhiye. Clinical characteristics and surgical management of endometriosis-associated infertility: A multicenter prospective cohort study. Int J Gynaecol Obstet 2022;159(1):86–96.
Amy L Shafrir, Allison F Vitonis, Britani Wallace, Amy D DiVasta, Jenny Sadler Gallagher, Naoko Sasamoto, Marc R Laufer, Kathryn L Terry, Stacey A Missmer. Cohort profile: The Endometriosis pain QUality aftEr Surgical Treatment (EndoQUEST) Study. PLoS One 2022;17(6):e0269858.
Bethan Swift, Huseyin Naci, Bahar Taneri, Christian M Becker, Krina T Zondervan, Nilufer Rahmioglu. The Cyprus Women’s Health Research (COHERE) Initiative: normative data from the SF-36v2 questionnaire for reproductive aged women from the Eastern Mediterranean. Qual Life Res 2022;31(7):2011-2022.
Naoko Sasamoto, Oana A Zeleznik, Allison F Vitonis, Stacey A Missmer, Marc R Laufer, Julian Avila-Pacheco, Clary B Clish, Kathryn L Terry. Presurgical blood metabolites and risk of postsurgical pelvic pain in young patients with endometriosis. Fertil Steril. 2022;117(6):1235-45.
Naoko Sasamoto, Long Ngo, Allison F Vitonis, Simon T Dillon, Stacey A Missmer, Towia A Libermann, Kathryn L Terry. Circulating proteomic profiles associated with endometriosis in adolescents and young adults. Hum Reprod 2022;37(9):2042-53.
Iwona Gabriel, Allison F Vitonis, Stacey A Missmer, Ayòtúndé Fadayomi, Amy D DiVasta, Kathryn L Terry, Vatche A Minassian..Association between endometriosis and lower urinary tract symptoms. Fertil Steril 2022;117(4):822-30.
Natasha L Orr, Kate J Wahl, Michelle Lisonek, Angela Joannou, Heather Noga, Arianne Albert, Mohamed A Bedaiwy, Christina Williams, Catherine Allaire, Paul J Yong. Central sensitization inventory in endometriosis. Pain 2022;163(2):e234-e245.
Aishwarya V. Bhurke, Pramathes DasMahapatra, Sheila Balakrishnan, Shagufta A. Khan, Sally Mortlock, Vinita Das, Nirmala Chellamma, Sowmini Cheruvara Vadakkathil, Aarti Srivastava, Amiya Majumdar, Achhelal Pasi, Geetanjali Sachdeva, Grant W. Montgomery, Rahul K. Gajbhiye. Clinical characteristics and surgical management of endometriosis-associated infertility: A multicenter prospective cohort study. Int J Gynaecol Obstet 2022;159(1):86-96.
Jaclyn C Watkins, Amy D DiVasta, Allison F Vitonis, Christopher P Crum, Marc R Laufer, Kathryn L Terry, Brooke E Howitt, Stacey A Missmer. A Clinical and Pathologic Exploration of Suspected Peritoneal Endometriotic Lesions. Int J Gynecol Pathol 2021;40(6):602-10.
Thomas T Tapmeier, Nilufer Rahmioglu, Jianghai Lin, Bianca De Leo, Maik Obendorf, Muthuswamy Raveendran, Oliver M Fischer, Cemsel Bafligil, Manman Guo, Ronald Alan Harris, Holger Hess-Stumpp, Alexis Laux-Biehlmann, Ernesto Lowy, Gerton Lunter, Jessica Malzahn, Nicholas G Martin, Fernando O Martinez, Sanjiv Manek, Stefanie Mesch, Grant W Montgomery, Andrew P Morris, Jens Nagel Heather A Simmons, Denise Brocklebank, Catherine Shang, Susan Treloar, Graham Wells, Christian M Becker, Udo Oppermann, Thomas M Zollner, Stephen H Kennedy, Joseph W Kemnitz, Jeffrey Rogers, Krina T Zondervan. Neuropeptide S receptor 1 is a nonhormonal treatment target in endometriosis. Sci Transl Med 2021;13(608):eabd6469.
Douglas A Gibson, Frances Collins, Bianca De Leo, Andrew W Horne, Philippa T K Saunders. Pelvic pain correlates with peritoneal macrophage abundance not endometriosis. Reprod Fertil 2021;2(1):47-57.
Idhaliz Flores-Caldera, Paola M Ramos-Echevarría, José A Oliveras-Torres, Natasha Santos-Piñero, Estefanía D Rivera-Mudafort, Denisse M Soto-Soto, Brian Hernández-Colón, Luis E Rivera-Hiraldo, Loraine Mas, Mary Rodríguez-Rabassa, Nabal J Bracero, Edgardo Rolla; Ibero-American Endometriosis Association. Ibero-American Endometriosis Patient Phenome: Demographics, Obstetric-Gynecologic Traits, and Symptomatology. Front Reprod Health 2021;3:667345.
Amy D DiVasta, Lori A Zimmerman, Allison F Vitonis, Ayotunde B Fadayomi, Stacey A Missmer. Overlap Between Irritable Bowel Syndrome Diagnosis and Endometriosis in Adolescents. Clin Gastroenterol Hepatol 2021;19(3):528-37.e1.
Amy L Shafrir, Marissa C Palmor, Jessica Fourquet, Amy D DiVasta, Leslie V Farland, Allison F Vitonis, Holly R Harris, Marc R Laufer, Daniel W Cramer, Kathryn L Terry, Stacey A Missmer. Co-occurrence of immune-mediated conditions and endometriosis among adolescents and adult women. Am J Reprod Immunol 2021;86(1):e13404.
Mira Mousa, Moamar Al-Jefout, Habiba Alsafar, Christian M Becker, Krina T Zondervan, Nilufer Rahmioglu. Impact of endometriosis in women of Arab ancestry on: health-related quality of life, work productivity, and diagnostic delay. Front Glob Womens Health 2021;2:708410.
Naoko Sasamoto, Mary DePari, Allison F Vitonis, Marc R Laufer, Stacey A Missmer, Amy L Shafrir, Kathryn L Terry. Evaluation of CA125 in relation to pain symptoms among adolescents and young adult women with and without surgically-confirmed endometriosis. PLoS One. 2020;15(8):e0238043.
Manman Guo, Cemsel Bafligil, Thomas Tapmeier, Carol Hubbard, Sanjiv Manek, Catherine Shang, Fernando O Martinez, Nicole Schmidt, Maik Obendorf, Holger Hess-Stumpp, Thomas M Zollner, Stephen Kennedy, Christian M Becker, Krina T Zondervan, Adam P Cribbs, Udo Oppermann. Mass cytometry analysis reveals a distinct immune environment in peritoneal fluid in endometriosis: a characterisation study. BMC Med 2020;18(1):3.
Madeline P Schneider, Allison F Vitonis, Ayotunde B Fadayomi, Brittany M Charlton, Stacey A Missmer, Amy D DiVasta. Quality of Life in Adolescent and Young Adult Women With Dyspareunia and Endometriosis. J Adolesc Health 2020;67(4):557-61.
Hannah M Nazri, Maria Imran, Roman Fischer, Raphael Heilig, Sanjiv Manek, Rebecca A Dragovic, Benedikt M Kessler, Krina T Zondervan, Thomas T Tapmeier, Christian M Becker. Characterization of exosomes in peritoneal fluid of endometriosis patients. Fertil Steril 2020;113(2):364-373.e2.
Inigu Urteaga, Mollie McKillop, Noémie Elhadad. Learning endometriosis phenotypes from patient-generated data. NPJ Digit Med 2020;3:88.
Naoko Sasamoto, Leslie V Farland, Allison F Vitonis, Holly R Harris, Amy D DiVasta, Marc R Laufer, Kathryn L Terry, Stacey A Missmer. In utero and early life exposures in relation to endometriosis in adolescents and young adults. Eur J Obstet Gynecol Reprod Biol 2020;252:393-98.
Marie-Laëtitia Thézénas, Bianca De Leo, Alexis Laux-Biehlmann, Cemsel Bafligil, Bernd Elger, Thomas Tapmeier, Karl Morten, Nilufer Rahmioglu, Stephanie G Dakin, Philip Charles, Fernando Estrada Martinez, Graham Steers, Oliver M Fischer, Joerg Mueller, Holger Hess-Stumpp, Andreas Steinmeyer, Sanjiv Manek, Krina T Zondervan, Stephen Kennedy, Christian M Becker, Catherine Shang, Thomas M Zollner, Benedikt M Kessler, Udo Oppermann. Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions. Sci Rep 2020;10(1):1495.
M B Hocaoglu, S Gurkas, T Karaderi, B Taneri, K Erguler, B Barin, E M Bilgin, G Eralp, M Allison, N Findikli, K Boynukalin, M Bahceci, H Naci, K Vincent, S A Missmer, C M Becker, K T Zondervan, N Rahmioglu. Cyprus Women's Health Research (COHERE) initiative: determining the relative burden of women's health conditions and related co-morbidities in an Eastern Mediterranean population. BMC Womens Health 2019;19(1):50.
Andrew W Horne, S Furquan Ahmad, Roderick Carter, Ioannis Simitsidellis, Erin Greaves, Chloe Hogg, Nicholas M Morton, Philippa T K Saunders. Repurposing dichloroacetate for the treatment of women with endometriosis. Proc Natl Acad Sci U S A. 2019;116(51):25389-25391.
Jenny Sadler Gallagher, Amy D DiVasta, Allison F Vitonis, Vishnudas Sarda, Marc R Laufer, Stacey A Missmer. The Impact of Endometriosis on Quality of Life in Adolescents. J Adolesc Health 2018;63(6):766-72.
Amy D DiVasta, Allison F Vitonis, Marc R Laufer, Stacey A Missmer. Spectrum of symptoms in women diagnosed with endometriosis during adolescence vs adulthood. Am J Obstet Gynecol 2018;218(3):324.e1-324.e11
Jerri A Miller, Stacey A Missmer, Allison F Vitonis, Vishnudas Sarda, Marc R Laufer, Amy D DiVasta. Prevalence of migraines in adolescents with endometriosis. Fertil Steril 2018;109(4):685-690.
Nilufer Rahmioglu, Alexander W Drong, Helen Lockstone, Thomas Tapmeier, Karin Hellner, Merli Saare, Triin Laisk-Podar, Christine Dew, Emily Tough, George Nicholson, Maire Peters, Andrew P Morris, Cecilia M Lindgren, Christian M Becker, Krina T Zondervan. Variability of genome-wide DNA methylation and mRNA expression profiles in reproductive and endocrine disease related tissues. Epigenetics 2017;12(10):897-908.
Erin Greaves, Julia Temp, Arantza Esnal-Zufiurre, Sylvia Mechsner, Andrew W Horne, Philippa T K Saunders. Estradiol is a critical mediator of macrophage-nerve cross talk in peritoneal endometriosis. Am J Pathol 2015;185(8):2286-97.
Vicky J Young, Jeremy K Brown, Philippa T K Saunders, W Colin Duncan, Andrew W Horne. The peritoneum is both a source and target of TGF-β in women with endometriosis. PLoS One 2014;9(9):e106773.
Erin Greaves, Kelsey Grieve, Andrew W Horne, Philippa T K Saunders. Elevated peritoneal expression and estrogen regulation of nociceptive ion channels in endometriosis. J Clin Endocrinol Metab 2014;99(9):E1738-E1743.
Arezoo Arabipoor, Kiandokht Kiani, Abbas Ebadi, Ashraf Moini, Zahra Zolfaghari, Mohadeseh Goudarzi. The Translation and Cross-Cultural Adaptation of The Persian Version of The WERF EPHect Endometriosis Patient Questionnaire: A Cross-Sectional Study. Int J Fertil Steril 2025;19(4):394-401.
Gabriele Barbosa Anelli, Rafael Zucco de Oliveira, Juliana Meola, Daniela Michelazzo, Ricardo Perussi-e-Silva, Julio Cesar Rosa-e-Silva, Christian Becker, Nilufer Rahmioglu, Lone Hummelshoj, Stacey Missmer, Krina Zondervan, Omero Benedicto Poli-Neto. Translation, cross-cultural adaptation into Brazilian Portuguese and electronic migration of the WERF EPHect endometriosis patient questionnaire. Revista Brasileira de Ginecologia e Obstetrícia 2025;47:e-rbgo40.
Line Holdgaard Thomsen, Laura Emilie Vexø, Tine Henrichsen Schnack, Karina Ejgaard Hansen, Axel Forman, Dorthe Hartwell, Henriette Svarre Nielsen, Lone Hummelshoj, Mette Nyegaard, Mette Elkjær Madsen. Danish translation, cross-cultural adaptation, and electronic migration of the World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project Endometriosis Patient Questionnaire. Front Glob Womens Health 2023;4:1102006.
Idhaliz Flores-Caldera, Paola M Ramos-Echevarría, José A Oliveras-Torres, Natasha Santos-Piñero, Estefanía D Rivera-Mudafort, Denisse M Soto-Soto, Brian Hernández-Colón, Luis E Rivera-Hiraldo, Loraine Mas, Mary Rodríguez-Rabassa, Nabal J Bracero, Edgardo Rolla; Ibero-American Endometriosis Association. Ibero-American Endometriosis Patient Phenome: Demographics, Obstetric-Gynecologic Traits, and Symptomatology. Front Reprod Health 2021:3:667345.
Cise Mis, Gokcen Kofali, Bethan Swift, Pinar Yalcin Bahat, Gamze Senocak, Bahar Taneri, Lone Hummelshoj, Stacey A Missmer, Christian M Becker, Krina T Zondervan, Bahar Yuksel Ozgor, Engin Oral, Umit Inceboz, Mevhibe B Hocaoglu, Nilufer Rahmioglu. Protocol for the Cultural Translation and Adaptation of the World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project Endometriosis Participant Questionnaire (EPHect). Front Glob Womens Health 2021;2:644609.
Evan Dimentberg, Claire Cardaillac, Evelyn Richard, Anne-Sophie Plante, Sarah Maheux-Lacroix. Translation and Cultural Validation of the WERF EPHect Endometriosis Patient Questionnaire into Canadian French. J Obstet Gynaecol Can 2021;43(7):817-821.
Being updated ...
Lone Hummelshoj, Daniëlle Peterse, Kaylon L Bruner-Tran, Stacey A Missmer, Erin Greaves. Enhancing collaboration in endometriosis research through the initiative of the World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project (EPHect). Mol Hum Reprod 2025;31(3):Epub.
Katherine A Burns, Daniëlle Peterse, Caroline B Appleyard, Ronald Chandler, Sun-Wei Guo, Amelia Pearson, Eleonora Persoons, Michael S Anglesio, Michael S Rogers, Kathy L Sharpe-Timms, Joris Vriens, Stacey L McAllister, Kelsi N Dodds, Fiona L Cousins, Lone Hummelshoj, Stacey A Missmer, Kaylon L Bruner-Tran, Erin Greaves, for the EPHect Experimental Models Working Group. WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Homologous): homologous rodent models. Mol Hum Reprod 2025;31(3):Epub.
M Louise Hull, Raul Gomez, Warren B Nothnick, Ruth Gruemmer, Katherine A Burns, Mohammed Zahied Johan, Isabella R Land, Stacey A Missmer, Lone Hummelshoj, Erin Greaves, Kaylon L Bruner-Tran, for the EPHect Experimental Models Working Group. WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Heterologous): heterologous rodent models. Mol Hum Reprod 2025;31(3):Epub.
Kelsi N Dodds, Victor Fattori, Nick A Andrews, Caroline B Appleyard, Julie A Christianson, Raul Gomez, Stacy L McAllister, Stacey A Missmer, Jens Nagel, Paulina Nunez-Badinez, Michael S. Rogers, Philippa TK Saunders, Miguel A Tejada, Katy Vincent, Lone Hummelshoj, Kaylon L Bruner-Tran, Erin Greaves, for the EPHect Experimental Models Working Group. WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Pain): methods to assess pain behaviour in rodent models of endometriosis. Mol Hum Reprod 2025;31(3):Epub.
Elizabeth E Marr, Juan S Gnecco, Stacey A Missmer, Shannon M Hawkins, Kevin G Osteen, Lone Hummelshoj, Erin Greaves, and Kaylon L Bruner-Tran, for the EPHect-Experimental Models Working Group. WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Organoids): endometrial organoids as an emerging technology for endometriosis research. Mol Hum Reprod 2025;31(3):Epub.
Tinya Lin, Catherine Allaire, Sawsan As-Sanie, Pamela Stratton, Katy Vincent, G David Adamson, Lars Arendt-Nielsen, Deborah Bush, Femke Jansen, Jennifer Longpre, Luk Rombauts, Jay Shah, Abeesha Toussaint, Lone Hummelshoj, Stacey A Missmer, Paul J Yong; WERF EPHect Physical Examination Working Group. World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project: V. Physical examination standards in endometriosis research. Fertil Steril 2024;122(2):304-15.
Christian M Becker, Marc R Laufer, Pamela Stratton, Lone Hummelshoj, Stacey A Missmer, Krina T Zondervan, G David Adamson; WERF EPHect Working Group. World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: I. Surgical phenotype data collection in endometriosis research. Fertil Steril 2014;102(5):1213-1222.
Allison F Vitonis, Katy Vincent, Nilufer Rahmioglu, Amelie Fassbender, Germaine M Buck Louis, Lone Hummelshoj, Linda C Giudice, Pamela Stratton, G David Adamson, Christian M Becker, Krina T Zondervan, Stacey A Missmer; WERF EPHect Working Group. World Endometriosis Research Foundation (WERF) Endometriosis Phenome and biobanking harmonization project (EPHect): II. Clinical and covariate phenotype data collection in endometriosis research. Fertil Steril 2014;102(5):1223-32.
Nilufer Rahmioglu, Amelie Fassbender, Allison F Vitonis, Shelley S Tworoger, Lone Hummelshoj, Thomas M D'Hooghe, G David Adamson, Linda C Giudice, Christian M Becker, Krina T Zondervan, Stacey A Missmer; WERF EPHect Working Group. WERF Endometriosis Phenome and Biobanking Harmonization Project (EPHect): III. Fluid biospecimen collection, processing, and storage in endometriosis research. Fertil Steril 2014;102(5):1233-43.
Amelie Fassbender, Nilufer Rahmioglu, Allison F Vitonis, Paola Viganò, Linda C Giudice, Thomas M D'Hooghe, Lone Hummelshoj, G David Adamson, Christian M Becker, Stacey A Missmer, Krina T Zondervan; WERF EPHect Working Group. World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project (EPHect): IV. Tissue collection, processing, and storage in endometriosis research. Fertil Steril 2014;102(5):1244-53.
Casper RF. New tools for enhancing collaborative endometriosis research. Fertil Steril 2014;102(5):1211-12.
The first major projects of the World Endometriosis Research Foundation (WERF) were the Global Study of Women’s Health (GSWH) - the first prospective epidemiological study to investigate the impact of and risk-factors for endometriosis in ten countries (16 centres) across the world1 - and the Women’s Health Symptom Survey (WHSS) - the first prospective epidemiological study to investigate the predictability of endometriosis at a global level2.
To capture data across these centres, three forms were developed, which were later expanded and refined into what is now the EPHect EPQ and EPHect SSF:
The resulting publications include
© 2014-2026 ephect.org